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?????NF-κB (nuclear factor kappa-light-chain-enhancer of B cells) is a transcription factor that regulates expression of cytokines, growth factors, apoptosis inhibitors and effector enzyme in response to extracellular signals. NF-κB is composed of multiple subunits: RelA (p65), RelB, c-Rel, NF-κB1 (p50) and NF-κB2 (p52).